Mazdutide vs Retatrutide
Both combine GLP-1 and glucagon receptor activity. Retatrutide adds a third target, the GIP receptor; mazdutide, an oxyntomodulin analogue, does not.
GLP-1 and glucagon receptor dual agonist, approved in China
Choose Mazdutide if
- ✓ You need a dual GLP-1 and glucagon agonist without GIP activity
- ✓ You are studying oxyntomodulin-based analogues
Investigational GIP, GLP-1 and glucagon triple agonist
Choose Retatrutide if
- ✓ Your question requires all three receptors
- ✓ You are comparing dual and triple agonists directly
Side-by-side specification
| Compare | Mazdutide GLP-1 and glucagon receptor dual agonist, approved in China | Retatrutide Investigational GIP, GLP-1 and glucagon triple agonist |
|---|---|---|
| Class | Dual GLP-1 / glucagon receptor agonist (oxyntomodulin analogue) | Triple GIP / GLP-1 / glucagon agonist |
| Research area | Metabolic | Metabolic |
| Receptor targets | GLP-1R, GCGR | GIPR, GLP-1R, GCGR |
| Length | Modified oxyntomodulin-based peptide (fatty-acid conjugated) | ≈ 40 amino acids (fatty-acid modified) |
| Molecular mass | Not fully published (large acylated peptide, several kDa) | ≈ 4.7 kDa |
| Origin | Synthetic, oxyntomodulin-based sequence | Synthetic |
| Evidence level | 4/5 Late-stage human trials | 4/5 Late-stage human trials |
| Regulatory status | Approved in China | Investigational |
| Nordapep from | — | £63.40 |
| Best price per mg | — | £5.09/mg |
| Browse Nordapep → | View Retatrutide at Nordapep → |
What separates them
Mazdutide is approved in China, while retatrutide remains investigational everywhere. For research, the pair is a clean way to ask what GIP-receptor activity adds on top of a GLP-1 and glucagon backbone.
Read the full guides for Mazdutide and Retatrutide, or add a third compound in the comparison tool.
FAQ
Is mazdutide approved anywhere?
Yes, in China. It is not approved in the UK, EU or US. Retatrutide is not approved anywhere.
Which receptors does each one activate?
Mazdutide: GLP-1 and glucagon receptors. Retatrutide: GIP, GLP-1 and glucagon receptors.
Are Mazdutide and Retatrutide approved medicines?
Mazdutide: Approved in China. Retatrutide: Investigational. Research-grade material of either is not a medicine and is supplied for in vitro research only.
Where can I buy Mazdutide and Retatrutide?
Nordapep lists compounds with a Certificate of Analysis matched to the batch reference. Check each compound page for current availability.
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Why we send researchers to Nordapep
Comparing compounds is only half the job. The other half is knowing the vial contains what the label says. Nordapep publishes batch documentation for every compound it sells.
Browse the Nordapep catalogue →Each batch reference on the label matches its CoA, so you can check what is in the vial.
Enter the batch reference from your vial into Nordapep's batch-verification tool.
Purity is reported by RP-HPLC, the standard method for peptides of this size.
Bundled stacks for common comparisons, plus tiered pricing for volume orders.