Semaglutide vs Cagrilintide
These two act on different hormone systems. Semaglutide mimics GLP-1 and activates the GLP-1 receptor. Cagrilintide mimics amylin and activates amylin and calcitonin receptors. Both are acylated for a half-life of about a week.
Long-acting GLP-1 receptor agonist
Choose Semaglutide if
- ✓ You need the established GLP-1 reference compound
- ✓ Evidence maturity matters most for your design
Long-acting amylin and calcitonin receptor agonist
Choose Cagrilintide if
- ✓ Your question is about amylin or calcitonin receptor signalling
- ✓ You are studying how a second pathway adds to GLP-1 activity
Side-by-side specification
| Compare | Semaglutide Long-acting GLP-1 receptor agonist | Cagrilintide Long-acting amylin and calcitonin receptor agonist |
|---|---|---|
| Class | GLP-1 receptor agonist | Amylin / calcitonin receptor agonist |
| Research area | Metabolic | Metabolic |
| Receptor targets | GLP-1R | Amylin and calcitonin receptors |
| Length | 31 amino acids (acylated GLP-1 analogue) | 37 amino acids (acylated amylin analogue) |
| Molecular mass | ≈ 4.11 kDa | ≈ 4.41 kDa |
| Origin | Synthetic analogue of human GLP-1 | Synthetic analogue of human amylin |
| Evidence level | 5/5 Approved drug, phase 3 trials | 4/5 Late-stage human trials |
| Regulatory status | Approved prescription medicine | Investigational |
| Nordapep from | Not listed | Not listed |
| Best price per mg | Not listed | Not listed |
| View Semaglutide at Nordapep → | View Cagrilintide at Nordapep → |
What separates them
Semaglutide is an approved medicine and cagrilintide is investigational on its own. Their combination, CagriSema, was submitted to the FDA in December 2025 and was still under review at the time of writing.
Read the full guides for Semaglutide and Cagrilintide, or add a third compound in the comparison tool.
FAQ
What is CagriSema?
A fixed-dose combination of cagrilintide and semaglutide developed by Novo Nordisk. It is not approved at the time of writing.
Is cagrilintide a GLP-1 drug?
No. It targets the amylin and calcitonin receptors, not the GLP-1 receptor.
Are Semaglutide and Cagrilintide approved medicines?
Semaglutide: Approved prescription medicine. Cagrilintide: Investigational. Research-grade material of either is not a medicine and is supplied for in vitro research only.
Where can I buy Semaglutide and Cagrilintide?
Nordapep lists compounds with a Certificate of Analysis matched to the batch reference. Check each compound page for current availability.
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Where to buy
Why we send researchers to Nordapep
Comparing compounds is only half the job. The other half is knowing the vial contains what the label says. Nordapep publishes batch documentation for every compound it sells.
Browse the Nordapep catalogue →Each batch reference on the label matches its CoA, so you can check what is in the vial.
Enter the batch reference from your vial into Nordapep's batch-verification tool.
Purity is reported by RP-HPLC, the standard method for peptides of this size.
Bundled stacks for common comparisons, plus tiered pricing for volume orders.