Survodutide vs Retatrutide
The core difference is receptor coverage. Survodutide activates the GLP-1 and glucagon receptors; retatrutide activates those two plus the GIP receptor. Both are fatty-acid-modified for a long half-life and both are investigational, so neither is an approved medicine outside the regional exceptions noted on their pages.
Investigational GLP-1 and glucagon receptor dual agonist
Choose Survodutide if
- ✓ Your question isolates glucagon plus GLP-1 signalling
- ✓ You are studying liver-fat or energy-expenditure models
Investigational GIP, GLP-1 and glucagon triple agonist
Choose Retatrutide if
- ✓ Your question concerns triple-receptor signalling
- ✓ You want the compound with the larger research literature
Side-by-side specification
| Compare | Survodutide Investigational GLP-1 and glucagon receptor dual agonist | Retatrutide Investigational GIP, GLP-1 and glucagon triple agonist |
|---|---|---|
| Class | Dual GLP-1 / glucagon receptor agonist | Triple GIP / GLP-1 / glucagon agonist |
| Research area | Metabolic | Metabolic |
| Receptor targets | GLP-1R, GCGR | GIPR, GLP-1R, GCGR |
| Length | ≈ 29 amino acids (acylated, one non-coded residue) | ≈ 40 amino acids (fatty-acid modified) |
| Molecular mass | ≈ 4.23 kDa | ≈ 4.7 kDa |
| Origin | Synthetic, glucagon-based sequence | Synthetic |
| Evidence level | 4/5 Late-stage human trials | 4/5 Late-stage human trials |
| Regulatory status | Investigational | Investigational |
| Nordapep from | Not listed | £63.40 |
| Best price per mg | Not listed | £5.09/mg |
| View Survodutide at Nordapep → | View Retatrutide at Nordapep → |
What separates them
For research, survodutide is the cleaner tool when the question is what glucagon-receptor activity adds to GLP-1 activity. Retatrutide is the natural choice when the question is how a third (GIP) receptor changes the picture.
Read the full guides for Survodutide and Retatrutide, or add a third compound in the comparison tool.
FAQ
Do they share a receptor?
Yes. Both activate the GLP-1 and glucagon receptors; only retatrutide also activates the GIP receptor.
Is either approved?
Neither is approved by the MHRA, EMA or FDA. Both are investigational.
Are Survodutide and Retatrutide approved medicines?
Survodutide: Investigational. Retatrutide: Investigational. Research-grade material of either is not a medicine and is supplied for in vitro research only.
Where can I buy Survodutide and Retatrutide?
Nordapep lists compounds with a Certificate of Analysis matched to the batch reference. Check each compound page for current availability.
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Why we send researchers to Nordapep
Comparing compounds is only half the job. The other half is knowing the vial contains what the label says. Nordapep publishes batch documentation for every compound it sells.
Browse the Nordapep catalogue →Each batch reference on the label matches its CoA, so you can check what is in the vial.
Enter the batch reference from your vial into Nordapep's batch-verification tool.
Purity is reported by RP-HPLC, the standard method for peptides of this size.
Bundled stacks for common comparisons, plus tiered pricing for volume orders.