Glossary
GLP-1
Glucagon-like peptide-1, an incretin hormone released from the gut. A family of long-acting analogues targets its receptor.
Relevant compounds
- Semaglutide
Long-acting GLP-1 receptor agonist
- Liraglutide
First-generation acylated GLP-1 receptor agonist
- Tirzepatide
Dual GIP and GLP-1 receptor agonist
- Retatrutide
Investigational GIP, GLP-1 and glucagon triple agonist
- Cagrilintide
Long-acting amylin and calcitonin receptor agonist
- Exenatide
Gila-monster-derived GLP-1 receptor agonist
- Survodutide
Investigational GLP-1 and glucagon receptor dual agonist
- Mazdutide
GLP-1 and glucagon receptor dual agonist, approved in China
Further reading
- Semaglutide vs tirzepatide vs retatrutide: the three incretin peptides compared
How the three best-known incretin research compounds differ in receptor targets, evidence and regulatory status, with links to each head-to-head comparison.
- Incretin and amylin peptides explained: GLP-1, GIP, glucagon and amylin
A plain-English map of the receptors behind semaglutide, tirzepatide, retatrutide, cagrilintide and the earlier GLP-1 analogues, and how each added a target.