Tirzepatide vs Retatrutide
Retatrutide adds glucagon-receptor activity to the GIP and GLP-1 activity that tirzepatide already has. That third receptor is the whole story of the comparison.
Dual GIP and GLP-1 receptor agonist
Choose Tirzepatide if
- ✓ You want an approved, well-characterised dual agonist
- ✓ You need a stable dual-agonist baseline before testing a triple agonist
Investigational GIP, GLP-1 and glucagon triple agonist
Choose Retatrutide if
- ✓ Your research question involves glucagon-receptor activity
- ✓ You are working on the newest generation of incretin peptides
Side-by-side specification
| Compare | Tirzepatide Dual GIP and GLP-1 receptor agonist | Retatrutide Investigational GIP, GLP-1 and glucagon triple agonist |
|---|---|---|
| Class | Dual GIP / GLP-1 receptor agonist | Triple GIP / GLP-1 / glucagon agonist |
| Research area | Metabolic | Metabolic |
| Receptor targets | GIPR, GLP-1R | GIPR, GLP-1R, GCGR |
| Length | 39 amino acids (acylated) | ≈ 40 amino acids (fatty-acid modified) |
| Molecular mass | ≈ 4.81 kDa | ≈ 4.7 kDa |
| Origin | Synthetic, GIP-based sequence | Synthetic |
| Evidence level | 5/5 Approved drug, phase 3 trials | 4/5 Late-stage human trials |
| Regulatory status | Approved prescription medicine | Investigational |
| Nordapep from | Not listed | £63.40 |
| Best price per mg | Not listed | £5.09/mg |
| View Tirzepatide at Nordapep → | View Retatrutide at Nordapep → |
What separates them
Tirzepatide is approved and well characterised. Retatrutide is investigational, with published phase 2 data and a phase 3 programme in progress, so its evidence picture is still changing.
Read the full guides for Tirzepatide and Retatrutide, or add a third compound in the comparison tool.
FAQ
Is retatrutide just a stronger tirzepatide?
No. It is a different molecule with an extra receptor target. Comparisons of strength only make sense within one assay.
Are Tirzepatide and Retatrutide approved medicines?
Tirzepatide: Approved prescription medicine. Retatrutide: Investigational. Research-grade material of either is not a medicine and is supplied for in vitro research only.
Where can I buy Tirzepatide and Retatrutide?
Nordapep lists compounds with a Certificate of Analysis matched to the batch reference. Check each compound page for current availability.
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Why we send researchers to Nordapep
Comparing compounds is only half the job. The other half is knowing the vial contains what the label says. Nordapep publishes batch documentation for every compound it sells.
Browse the Nordapep catalogue →Each batch reference on the label matches its CoA, so you can check what is in the vial.
Enter the batch reference from your vial into Nordapep's batch-verification tool.
Purity is reported by RP-HPLC, the standard method for peptides of this size.
Bundled stacks for common comparisons, plus tiered pricing for volume orders.