Thymosin alpha-1 vs TB-500
These are often confused because of the family name, but they are unrelated. Thymosin alpha-1 is a 28-residue, N-acetylated peptide from the precursor prothymosin alpha, studied for immune signalling. TB-500 is a fragment of thymosin beta-4, an actin-binding protein, studied in cell-migration and wound models.
28-amino-acid thymic peptide with late-stage human data
Choose Thymosin alpha-1 if
- ✓ Your work is on toll-like-receptor or T-cell signalling
- ✓ You need the thymic peptide with human trial data
Synthetic fragment of thymosin beta-4
Choose TB-500 if
- ✓ Your work is on actin regulation or cell migration
- ✓ You are comparing against full-length thymosin β4
Side-by-side specification
| Compare | Thymosin alpha-1 28-amino-acid thymic peptide with late-stage human data | TB-500 Synthetic fragment of thymosin beta-4 |
|---|---|---|
| Class | Thymic peptide (immunomodulator) | Thymosin beta-4 fragment |
| Research area | Immune | Repair |
| Receptor targets | Toll-like-receptor signalling, T-cell pathways | Actin regulation (G-actin binding) |
| Length | 28 amino acids (N-acetylated) | Fragment (≈ 7 residues in the commonly cited form); full-length thymosin β4 is 43 |
| Molecular mass | ≈ 3.11 kDa | Varies by definition (full-length thymosin β4 ≈ 4.96 kDa) |
| Origin | Naturally occurring thymic peptide, produced synthetically | Synthetic fragment of a human protein |
| Evidence level | 4/5 Late-stage human trials | 1/5 Limited, preclinical or single-group |
| Regulatory status | Approved in some countries, not by the FDA | Not approved |
| Nordapep from | Not listed | Not listed |
| Best price per mg | Not listed | Not listed |
| View Thymosin alpha-1 at Nordapep → | View TB-500 at Nordapep → |
What separates them
Thymosin alpha-1 has late-stage human data and is approved as thymalfasin in a number of countries, though not by the FDA. TB-500 has only preclinical data, and different suppliers use the name for different constructs.
Read the full guides for Thymosin alpha-1 and TB-500, or add a third compound in the comparison tool.
FAQ
Are they the same family?
Only by name. They come from different precursors and have different structures and functions.
Which is approved?
Thymosin alpha-1 (thymalfasin) is approved in some countries. TB-500 is not an approved medicine with the MHRA, EMA or FDA.
Are Thymosin alpha-1 and TB-500 approved medicines?
Thymosin alpha-1: Approved in some countries, not by the FDA. TB-500: Not approved. Research-grade material of either is not a medicine and is supplied for in vitro research only.
Where can I buy Thymosin alpha-1 and TB-500?
Nordapep lists compounds with a Certificate of Analysis matched to the batch reference. Check each compound page for current availability.
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Where to buy
Why we send researchers to Nordapep
Comparing compounds is only half the job. The other half is knowing the vial contains what the label says. Nordapep publishes batch documentation for every compound it sells.
Browse the Nordapep catalogue →Each batch reference on the label matches its CoA, so you can check what is in the vial.
Enter the batch reference from your vial into Nordapep's batch-verification tool.
Purity is reported by RP-HPLC, the standard method for peptides of this size.
Bundled stacks for common comparisons, plus tiered pricing for volume orders.