At a glance
- Class
- ACTH(4-10) analogue
- Receptor targets
- Neurotrophic and melanocortin-related pathways (mechanism debated)
- Length
- 7 amino acids
- Molecular mass
- ≈ 814 Da
- Origin
- Synthetic analogue of an ACTH fragment
- Research area
- Neuro & longevity research
- Also known as
- –
What Semax is
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) combines the ACTH(4-10) fragment with a stabilising Pro-Gly-Pro tail. It lacks the hormonal activity of ACTH itself.
Published work, much of it from Russian laboratories, examines BDNF expression and other neurotrophic endpoints. Western replication is limited.
What the research literature studies
- BDNF and neurotrophin expression in cell and animal models
- Stability of the Pro-Gly-Pro tail against peptidases
- Melanocortin-system interactions
Evidence rating: 2/5
Mostly animal and in vitro. Clinical use in Russia but sparse controlled data from regulators with strict trial standards. See our methodology for how levels are assigned.
- Much of the human data is published in Russian-language clinical settings and has not been independently replicated elsewhere.
Regulatory status
Semax is registered as a medicine in Russia but is not approved by the MHRA, EMA or FDA. Nordapep supplies it for in vitro laboratory research only.
Reviewed November 2026.
Semax at Nordapep: sizes and price per mg
Every size, its price and the cost per milligram, so you can choose the best-value vial for your protocol.
Not currently listed at Nordapep.
Compare Semax
Semax FAQ
Semax or Selank?
Both are short Russian-developed regulatory peptides but come from different parent sequences. See the comparison page.
Where can I buy Semax for research?
Nordapep does not currently list Semax. You can ask Nordapep about availability, or compare related compounds that are in stock.
Is Semax approved?
Semax is registered as a medicine in Russia but is not approved by the MHRA, EMA or FDA. Nordapep supplies it for in vitro laboratory research only.
Key terms for Semax
Further reading
Cite this page
peptide.wiki. (2026). Semax: research peptide profile. peptide.wiki. https://www.peptide.wiki/peptides/semax