Pramlintide vs Cagrilintide
Both are amylin analogues, but they come from different design strategies. Pramlintide is a 37-residue human amylin with three proline substitutions, a short-acting soluble version. Cagrilintide is an acylated analogue built for a much longer duration.
Soluble amylin analogue
Choose Pramlintide if
- ✓ You need the approved reference amylin analogue
- ✓ Your question concerns amylin aggregation and proline substitution
Long-acting amylin and calcitonin receptor agonist
Choose Cagrilintide if
- ✓ Your question concerns acylated, long-acting design
- ✓ You are studying amylin-plus-GLP-1 pairing
Side-by-side specification
| Compare | Pramlintide Soluble amylin analogue | Cagrilintide Long-acting amylin and calcitonin receptor agonist |
|---|---|---|
| Class | Amylin receptor agonist | Amylin / calcitonin receptor agonist |
| Research area | Metabolic | Metabolic |
| Receptor targets | Amylin receptors (calcitonin receptor with RAMPs) | Amylin and calcitonin receptors |
| Length | 37 amino acids (C-terminal amide, one disulfide bond) | 37 amino acids (acylated amylin analogue) |
| Molecular mass | ≈ 3.95 kDa | ≈ 4.41 kDa |
| Origin | Synthetic, modified human amylin | Synthetic analogue of human amylin |
| Evidence level | 5/5 Approved drug, phase 3 trials | 4/5 Late-stage human trials |
| Regulatory status | Approved prescription medicine | Investigational |
| Nordapep from | Not listed | Not listed |
| Best price per mg | Not listed | Not listed |
| View Pramlintide at Nordapep → | View Cagrilintide at Nordapep → |
What separates them
For research, pramlintide is the established approved reference for amylin receptor pharmacology. Cagrilintide is the reference for long-acting amylin analogue design.
Read the full guides for Pramlintide and Cagrilintide, or add a third compound in the comparison tool.
FAQ
Do they act on the same receptors?
Yes, both act on amylin receptors; cagrilintide is also reported to have activity at related receptors.
Which has more clinical history?
Pramlintide has been approved for longer, while cagrilintide's programme is more recent.
Are Pramlintide and Cagrilintide approved medicines?
Pramlintide: Approved prescription medicine. Cagrilintide: Investigational. Research-grade material of either is not a medicine and is supplied for in vitro research only.
Where can I buy Pramlintide and Cagrilintide?
Nordapep lists compounds with a Certificate of Analysis matched to the batch reference. Check each compound page for current availability.
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Why we send researchers to Nordapep
Comparing compounds is only half the job. The other half is knowing the vial contains what the label says. Nordapep publishes batch documentation for every compound it sells.
Browse the Nordapep catalogue →Each batch reference on the label matches its CoA, so you can check what is in the vial.
Enter the batch reference from your vial into Nordapep's batch-verification tool.
Purity is reported by RP-HPLC, the standard method for peptides of this size.
Bundled stacks for common comparisons, plus tiered pricing for volume orders.