At a glance
- Class
- Amylin receptor agonist
- Receptor targets
- Amylin receptors (calcitonin receptor with RAMPs)
- Length
- 37 amino acids (C-terminal amide, one disulfide bond)
- Molecular mass
- ≈ 3.95 kDa
- Origin
- Synthetic, modified human amylin
- Research area
- Metabolic & incretin research
- Also known as
- Symlin, Amylin analogue
What Pramlintide is
Human amylin is released from pancreatic beta cells alongside insulin after meals. It slows gastric emptying, suppresses glucagon and contributes to satiety signalling. Native amylin is highly prone to forming amyloid aggregates, so it cannot be used as a drug itself.
Pramlintide solves this by swapping residues 25, 28 and 29 for proline, borrowing the pattern seen in rat amylin. It was approved by the FDA in the mid-2000s as an add-on to mealtime insulin, and remains the reference amylin analogue against which newer long-acting compounds such as cagrilintide are compared.
What the research literature studies
- Amylin receptor pharmacology and RAMP selectivity
- Aggregation behaviour of amylin and its analogues
- Reference comparisons for long-acting amylin analogues
Evidence rating: 5/5
Approved drug, phase 3 trials. Approved medicine with a completed phase 3 programme, used only as an add-on therapy. See our methodology for how levels are assigned.
- Short duration of action, which long-acting analogues were built to improve.
- Its clinical use is narrow, so most newer literature focuses on other amylin analogues.
Regulatory status
Pramlintide is an approved prescription medicine in the United States for use alongside mealtime insulin. It is not approved in every region. Research-grade material must not be used in people or animals.
Reviewed November 2026.
Pramlintide at Nordapep: sizes and price per mg
Every size, its price and the cost per milligram, so you can choose the best-value vial for your protocol.
Not currently listed at Nordapep.
Compare Pramlintide
Pramlintide FAQ
Why does pramlintide contain proline?
Proline residues disrupt the beta-sheet structures that drive amyloid aggregation. Substituting three of them keeps amylin-like activity while making the peptide soluble.
Pramlintide or cagrilintide?
Both act on amylin receptors; cagrilintide is a newer, acylated, longer-acting analogue. See the comparison page.
Where can I buy Pramlintide for research?
Nordapep does not currently list Pramlintide. You can ask Nordapep about availability, or compare related compounds that are in stock.
Is Pramlintide approved?
Pramlintide is an approved prescription medicine in the United States for use alongside mealtime insulin. It is not approved in every region. Research-grade material must not be used in people or animals.
Key terms for Pramlintide
Further reading
Cite this page
peptide.wiki. (2026). Pramlintide: research peptide profile. peptide.wiki. https://www.peptide.wiki/peptides/pramlintide