At a glance
- Class
- Dual GLP-1 / glucagon receptor agonist
- Receptor targets
- GLP-1R, GCGR
- Length
- ≈ 29 amino acids (acylated, one non-coded residue)
- Molecular mass
- ≈ 4.23 kDa
- Origin
- Synthetic, glucagon-based sequence
- Research area
- Metabolic & incretin research
- Also known as
- BI 456906
What Survodutide is
Survodutide (developed by Boehringer Ingelheim as BI 456906) is a roughly 29-residue synthetic peptide built on a glucagon-like backbone. A non-coded amino acid near the N-terminus resists breakdown by the enzyme DPP-4, and a C18 fatty diacid on a lysine side chain lets it bind albumin and stay in circulation.
Where semaglutide acts on GLP-1 alone and retatrutide adds GIP and glucagon, survodutide is a two-receptor design: GLP-1 plus glucagon. That makes it the reference point when researchers ask what glucagon-receptor activity contributes on its own, particularly in liver-fat models.
What the research literature studies
- GLP-1 and glucagon receptor signalling in cell-based assays
- How glucagon-receptor activity differs from GLP-1 activity in rodent energy-expenditure and liver-fat models
- Identity analysis of a large acylated peptide (HPLC and intact mass)
Evidence rating: 4/5
Late-stage human trials. Published phase 2 results and an ongoing phase 3 programme. Not yet approved. See our methodology for how levels are assigned.
- Long-term safety and efficacy data are still being generated; treat early readouts as provisional.
- Published sequence details differ between sources, so intact mass against a reference is the check that matters.
Regulatory status
Survodutide has not been approved by the MHRA, EMA or FDA. Research material is not a medicine, is not evaluated by any regulator, and must not be used in people or animals.
Reviewed November 2026.
Survodutide at Nordapep: sizes and price per mg
Every size, its price and the cost per milligram, so you can choose the best-value vial for your protocol.
Not currently listed at Nordapep.
Compare Survodutide
Survodutide FAQ
How does survodutide differ from retatrutide?
Survodutide activates two receptors, GLP-1 and glucagon. Retatrutide activates three: GIP, GLP-1 and glucagon. See the side-by-side comparison for structure, evidence level and regulatory status.
Is survodutide approved?
No. It is an investigational medicine. Research-grade material is supplied for in vitro laboratory work only.
Where can I buy Survodutide for research?
Nordapep does not currently list Survodutide. You can ask Nordapep about availability, or compare related compounds that are in stock.
Key terms for Survodutide
Cite this page
peptide.wiki. (2026). Survodutide: research peptide profile. peptide.wiki. https://www.peptide.wiki/peptides/survodutide