Tirzepatide vs Liraglutide
Liraglutide is a first-generation acylated GLP-1 analogue that acts on the GLP-1 receptor only. Tirzepatide is a later design that acts on both the GIP and GLP-1 receptors and carries a longer fatty diacid, giving it a half-life of days rather than hours.
Dual GIP and GLP-1 receptor agonist
Choose Tirzepatide if
- ✓ Your question involves GIP-receptor activity
- ✓ You need a long half-life reference compound
First-generation acylated GLP-1 receptor agonist
Choose Liraglutide if
- ✓ You need a GLP-1-only comparator with a long published record
- ✓ You are studying how acylation design affects half-life
Side-by-side specification
| Compare | Tirzepatide Dual GIP and GLP-1 receptor agonist | Liraglutide First-generation acylated GLP-1 receptor agonist |
|---|---|---|
| Class | Dual GIP / GLP-1 receptor agonist | GLP-1 receptor agonist |
| Research area | Metabolic | Metabolic |
| Receptor targets | GIPR, GLP-1R | GLP-1R |
| Length | 39 amino acids (acylated) | 31 amino acids (acylated GLP-1 analogue) |
| Molecular mass | ≈ 4.81 kDa | ≈ 3.75 kDa |
| Origin | Synthetic, GIP-based sequence | Analogue of human GLP-1 |
| Evidence level | 5/5 Approved drug, phase 3 trials | 5/5 Approved drug, phase 3 trials |
| Regulatory status | Approved prescription medicine | Approved prescription medicine |
| Nordapep from | — | — |
| Best price per mg | — | — |
| Browse Nordapep → | Browse Nordapep → |
What separates them
Both are approved medicines at the top of our evidence scale. For research, liraglutide is the older single-receptor benchmark, and tirzepatide shows what a second receptor and a longer-acting design change.
Read the full guides for Tirzepatide and Liraglutide, or add a third compound in the comparison tool.
FAQ
Which has the longer half-life?
Tirzepatide, at about five days. Liraglutide's is about 13 hours.
Are both approved medicines?
Yes. Research-grade material is not those medicines and is for in vitro use only.
Are Tirzepatide and Liraglutide approved medicines?
Tirzepatide: Approved prescription medicine. Liraglutide: Approved prescription medicine. Research-grade material of either is not a medicine and is supplied for in vitro research only.
Where can I buy Tirzepatide and Liraglutide?
Nordapep lists compounds with a Certificate of Analysis matched to the batch reference. Check each compound page for current availability.
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Where to buy
Why we send researchers to Nordapep
Comparing compounds is only half the job. The other half is knowing the vial contains what the label says. Nordapep publishes batch documentation for every compound it sells.
Browse the Nordapep catalogue →Each batch reference on the label matches its CoA, so you can check what is in the vial.
Enter the batch reference from your vial into Nordapep's batch-verification tool.
Purity is reported by RP-HPLC, the standard method for peptides of this size.
Bundled stacks for common comparisons, plus tiered pricing for volume orders.