Tesamorelin vs Sermorelin
Both are analogues of growth hormone-releasing hormone and act on the same GHRH receptor. Sermorelin is the shortest fully active fragment, 29 amino acids. Tesamorelin keeps all 44 and adds a hexenoyl group at the N-terminus that slows enzymatic breakdown.
Stabilised full-length GHRH analogue
Choose Tesamorelin if
- ✓ You need a stabilised full-length GHRH analogue
- ✓ You want the comparator with phase 3 data behind it
Shortest fully active fragment of GHRH
Choose Sermorelin if
- ✓ You need the shortest active GHRH fragment as a reference
- ✓ Your question is about the native sequence without a stabilising modification
Side-by-side specification
| Compare | Tesamorelin Stabilised full-length GHRH analogue | Sermorelin Shortest fully active fragment of GHRH |
|---|---|---|
| Class | GHRH receptor agonist | GHRH receptor agonist |
| Research area | GH axis | GH axis |
| Receptor targets | GHRH-R | GHRH receptor |
| Length | 44 amino acids (hexenoyl-modified) | 29 amino acids (C-terminal amide) |
| Molecular mass | ≈ 5.14 kDa | ≈ 3.36 kDa |
| Origin | Synthetic analogue of human GHRH | Synthetic fragment of human GHRH |
| Evidence level | 5/5 Approved drug, phase 3 trials | 3/5 Early human trials |
| Regulatory status | Approved in the US for one indication | Formerly approved (discontinued) |
| Nordapep from | — | — |
| Best price per mg | — | — |
| Browse Nordapep → | Browse Nordapep → |
What separates them
For research, sermorelin is the minimal-sequence reference. Tesamorelin is the stabilised analogue and the one with the strongest evidence, because it is an approved medicine in the US for one indication.
Read the full guides for Tesamorelin and Sermorelin, or add a third compound in the comparison tool.
FAQ
What is the structural difference?
Sermorelin is GHRH(1-29) with a C-terminal amide. Tesamorelin is the full 44-residue sequence with a trans-3-hexenoyl group attached to the first residue.
Which has the higher evidence rating?
Tesamorelin, at level 5, because it is an approved medicine. Sermorelin is rated 3: it was approved in the past and later discontinued.
Are Tesamorelin and Sermorelin approved medicines?
Tesamorelin: Approved in the US for one indication. Sermorelin: Formerly approved (discontinued). Research-grade material of either is not a medicine and is supplied for in vitro research only.
Where can I buy Tesamorelin and Sermorelin?
Nordapep lists compounds with a Certificate of Analysis matched to the batch reference. Check each compound page for current availability.
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Where to buy
Why we send researchers to Nordapep
Comparing compounds is only half the job. The other half is knowing the vial contains what the label says. Nordapep publishes batch documentation for every compound it sells.
Browse the Nordapep catalogue →Each batch reference on the label matches its CoA, so you can check what is in the vial.
Enter the batch reference from your vial into Nordapep's batch-verification tool.
Purity is reported by RP-HPLC, the standard method for peptides of this size.
Bundled stacks for common comparisons, plus tiered pricing for volume orders.