Ipamorelin vs Sermorelin
They reach the same pituitary cells through different receptors. Ipamorelin is a five-residue agonist of the ghrelin receptor (GHS-R1a); sermorelin is the first 29 amino acids of GHRH and acts on the GHRH receptor.
Selective ghrelin-receptor agonist
Choose Ipamorelin if
- ✓ You are studying ghrelin-receptor (GHS-R1a) signalling
- ✓ You want a secretagogue reported as selective for growth hormone release in preclinical work
Shortest fully active fragment of GHRH
Choose Sermorelin if
- ✓ You need a GHRH-receptor reference based on the native sequence
- ✓ You want the compound with the longer clinical record
Side-by-side specification
| Compare | Ipamorelin Selective ghrelin-receptor agonist | Sermorelin Shortest fully active fragment of GHRH |
|---|---|---|
| Class | Ghrelin-receptor (GHS-R) agonist | GHRH receptor agonist |
| Research area | GH axis | GH axis |
| Receptor targets | GHS-R1a | GHRH receptor |
| Length | 5 amino acids | 29 amino acids (C-terminal amide) |
| Molecular mass | ≈ 712 Da | ≈ 3.36 kDa |
| Origin | Synthetic | Synthetic fragment of human GHRH |
| Evidence level | 2/5 Mostly animal and in vitro | 3/5 Early human trials |
| Regulatory status | Not approved | Formerly approved (discontinued) |
| Nordapep from | — | — |
| Best price per mg | — | — |
| Browse Nordapep → | Browse Nordapep → |
What separates them
For research, sermorelin is the reference for the natural GHRH signal and has a clinical history as a formerly approved product. Ipamorelin is the selective ghrelin-receptor tool, with far less human data behind it.
Read the full guides for Ipamorelin and Sermorelin, or add a third compound in the comparison tool.
FAQ
Do ipamorelin and sermorelin act on the same receptor?
No. Ipamorelin acts on the ghrelin receptor and sermorelin on the GHRH receptor. Both receptors sit on pituitary somatotroph cells, which is why the two are often studied side by side.
Is either one an approved medicine?
Sermorelin was approved in the past and later discontinued. Ipamorelin has never been approved. Research-grade material is for in vitro use only.
Are Ipamorelin and Sermorelin approved medicines?
Ipamorelin: Not approved. Sermorelin: Formerly approved (discontinued). Research-grade material of either is not a medicine and is supplied for in vitro research only.
Where can I buy Ipamorelin and Sermorelin?
Nordapep lists compounds with a Certificate of Analysis matched to the batch reference. Check each compound page for current availability.
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Where to buy
Why we send researchers to Nordapep
Comparing compounds is only half the job. The other half is knowing the vial contains what the label says. Nordapep publishes batch documentation for every compound it sells.
Browse the Nordapep catalogue →Each batch reference on the label matches its CoA, so you can check what is in the vial.
Enter the batch reference from your vial into Nordapep's batch-verification tool.
Purity is reported by RP-HPLC, the standard method for peptides of this size.
Bundled stacks for common comparisons, plus tiered pricing for volume orders.