PT-141 vs Kisspeptin-10
These peptides act on different receptor systems. PT-141 (bremelanotide) is a cyclic seven-residue agonist of melanocortin receptors, mainly MC4R. Kisspeptin-10 is a linear ten-residue agonist of the KISS1 receptor, which sits upstream of GnRH release.
Cyclic melanocortin-receptor agonist
Choose PT-141 if
- ✓ Your question is about melanocortin-receptor signalling
- ✓ You need a cyclic peptide with approved-medicine data
Shortest fully active fragment of kisspeptin
Choose Kisspeptin-10 if
- ✓ Your question is about the KISS1 receptor or GnRH regulation
- ✓ You are studying the hypothalamic reproductive axis
Side-by-side specification
| Compare | PT-141 Cyclic melanocortin-receptor agonist | Kisspeptin-10 Shortest fully active fragment of kisspeptin |
|---|---|---|
| Class | Melanocortin receptor agonist | KISS1 receptor agonist |
| Research area | Melanocortin | Neuroendocrine |
| Receptor targets | MC4R (also MC1R) | KISS1R (GPR54) |
| Length | 7 amino acids (cyclic) | 10 amino acids (C-terminal amide) |
| Molecular mass | ≈ 1.03 kDa | ≈ 1.30 kDa |
| Origin | Synthetic, derived from melanotan II | Fragment of human kisspeptin, produced synthetically |
| Evidence level | 5/5 Approved drug, phase 3 trials | 3/5 Early human trials |
| Regulatory status | Approved in the US only | Not approved |
| Nordapep from | — | — |
| Best price per mg | — | — |
| Browse Nordapep → | Browse Nordapep → |
What separates them
PT-141 is approved in the US and rated 5. Kisspeptin-10 is not approved and is rated 3, with human data limited to small physiology studies. For research, the pair contrasts a melanocortin pathway with the reproductive hormone axis.
Read the full guides for PT-141 and Kisspeptin-10, or add a third compound in the comparison tool.
FAQ
Do they share a mechanism?
No. PT-141 acts on melanocortin receptors in the central nervous system; kisspeptin-10 acts on the KISS1 receptor, which regulates GnRH neurons.
Which is cyclic?
PT-141. Kisspeptin-10 is a linear peptide with a C-terminal amide.
Are PT-141 and Kisspeptin-10 approved medicines?
PT-141: Approved in the US only. Kisspeptin-10: Not approved. Research-grade material of either is not a medicine and is supplied for in vitro research only.
Where can I buy PT-141 and Kisspeptin-10?
Nordapep lists compounds with a Certificate of Analysis matched to the batch reference. Check each compound page for current availability.
More comparisons
Where to buy
Why we send researchers to Nordapep
Comparing compounds is only half the job. The other half is knowing the vial contains what the label says. Nordapep publishes batch documentation for every compound it sells.
Browse the Nordapep catalogue →Each batch reference on the label matches its CoA, so you can check what is in the vial.
Enter the batch reference from your vial into Nordapep's batch-verification tool.
Purity is reported by RP-HPLC, the standard method for peptides of this size.
Bundled stacks for common comparisons, plus tiered pricing for volume orders.