At a glance
- Class
- GHRH receptor agonist
- Receptor targets
- GHRH receptor
- Length
- 29 amino acids (C-terminal amide)
- Molecular mass
- ≈ 3.36 kDa
- Origin
- Synthetic fragment of human GHRH
- Research area
- Growth-hormone axis
- Also known as
- GHRH (1-29), GRF 1-29, Geref
What Sermorelin is
Native GHRH is 44 residues long, but the first 29 carry essentially all of its receptor-binding and GH-releasing activity. Sermorelin reproduces that fragment as a C-terminal amide. It acts on the GHRH receptor in the pituitary, which is a different target from the ghrelin receptor addressed by ipamorelin or GHRP-6.
The branded product Geref was approved in the United States in 1997. The manufacturer discontinued it in 2008 for commercial reasons, and the FDA has stated it was not withdrawn for safety or effectiveness. Its very short half-life is the main reason longer-acting analogues such as CJC-1295 and tesamorelin were developed.
What the research literature studies
- GHRH receptor binding and signalling
- Structure-activity studies defining the minimal active GHRH fragment
- Reference comparisons for GHRH analogues with longer half-lives
Evidence rating: 3/5
Early human trials. Formerly an approved product with human trial data, but the approved product has been discontinued. See our methodology for how levels are assigned.
- Half-life of only minutes, which limits how it can be used in experimental designs.
- Most clinical literature dates from the 1980s to 2000s.
Regulatory status
The branded sermorelin product (Geref) is no longer marketed, and compounded or research-grade material does not carry the former approval. Research-grade material must not be used in people or animals.
Reviewed November 2026.
Sermorelin at Nordapep: sizes and price per mg
Every size, its price and the cost per milligram, so you can choose the best-value vial for your protocol.
Not currently listed at Nordapep.
Compare Sermorelin
Sermorelin FAQ
Is sermorelin a growth hormone?
No. It is an analogue of the hypothalamic hormone that prompts the pituitary to release growth hormone; it is not growth hormone itself.
Sermorelin or CJC-1295?
Both act on the GHRH receptor. CJC-1295 is a modified, longer-acting analogue. See the comparison page.
Where can I buy Sermorelin for research?
Nordapep does not currently list Sermorelin. You can ask Nordapep about availability, or compare related compounds that are in stock.
Is Sermorelin approved?
The branded sermorelin product (Geref) is no longer marketed, and compounded or research-grade material does not carry the former approval. Research-grade material must not be used in people or animals.
Key terms for Sermorelin
Further reading
Cite this page
peptide.wiki. (2026). Sermorelin: research peptide profile. peptide.wiki. https://www.peptide.wiki/peptides/sermorelin