Glossary
Half-life
The time for the concentration of a substance to fall by half. Chemical modifications are often made specifically to lengthen a peptide's half-life.
Relevant compounds
- Semaglutide
Long-acting GLP-1 receptor agonist
- Tirzepatide
Dual GIP and GLP-1 receptor agonist
- CJC-1295
GHRH analogue
- Liraglutide
First-generation acylated GLP-1 receptor agonist
- Cagrilintide
Long-acting amylin and calcitonin receptor agonist
- Kisspeptin-10
Shortest fully active fragment of kisspeptin
- Exenatide
Gila-monster-derived GLP-1 receptor agonist
- Sermorelin
Shortest fully active fragment of GHRH
Further reading
- Incretin and amylin peptides explained: GLP-1, GIP, glucagon and amylin
A plain-English map of the receptors behind semaglutide, tirzepatide, retatrutide, cagrilintide and the earlier GLP-1 analogues, and how each added a target.
- Growth hormone secretagogues explained: GHRH analogues versus ghrelin mimetics
Two receptors, two families. How sermorelin, CJC-1295 and tesamorelin differ from ipamorelin, GHRP-6 and hexarelin, and why the distinction matters for research design.