At a glance
- Class
- Mitochondria-targeted peptide
- Receptor targets
- Cardiolipin, inner mitochondrial membrane
- Length
- 4 amino acids (includes D-arginine and dimethyltyrosine)
- Molecular mass
- ≈ 640 Da
- Origin
- Synthetic
- Research area
- Mitochondrial & metabolic ageing
- Also known as
- Elamipretide, Bendavia, MTP-131
What SS-31 is
SS-31 belongs to the Szeto-Schiller family of peptides, built around alternating aromatic and basic residues, including the unnatural amino acid dimethyltyrosine, which help carry them into mitochondria.
It was first described as an antioxidant, but later work indicates it binds cardiolipin in the inner mitochondrial membrane and changes membrane structure and function. An earlier phase 3 trial in primary mitochondrial myopathy did not meet its primary endpoints, so the approval rests on a narrow, rare-disease evidence base.
What the research literature studies
- Cardiolipin binding and inner-membrane structure
- Mitochondrial respiration and reactive-oxygen readouts in cell models
- Cellular uptake of aromatic-cationic peptides
Evidence rating: 4/5
Late-stage human trials. Accelerated approval in one rare indication. Another phase 3 trial was negative. See our methodology for how levels are assigned.
- Accelerated approval depends on a confirmatory trial and covers one condition.
- Phase 3 results in another mitochondrial indication were negative.
Regulatory status
Elamipretide received FDA accelerated approval in September 2025 for a single rare condition, with a confirmatory trial required. We are not aware of an MHRA or EMA authorisation at the time of writing. Research-grade material is not that medicine and must not be used in people or animals.
Reviewed November 2026.
SS-31 at Nordapep: sizes and price per mg
Every size, its price and the cost per milligram, so you can choose the best-value vial for your protocol.
Not currently listed at Nordapep.
Compare SS-31
SS-31 FAQ
Is SS-31 the same as elamipretide?
Yes. SS-31 is the original research name and elamipretide is the generic name of the medicine.
Where can I buy SS-31 for research?
Nordapep does not currently list SS-31. You can ask Nordapep about availability, or compare related compounds that are in stock.
Is SS-31 approved?
Elamipretide received FDA accelerated approval in September 2025 for a single rare condition, with a confirmatory trial required. We are not aware of an MHRA or EMA authorisation at the time of writing. Research-grade material is not that medicine and must not be used in people or animals.
Cite this page
peptide.wiki. (2026). SS-31: research peptide profile. peptide.wiki. https://www.peptide.wiki/peptides/ss-31