At a glance
- Class
- α-MSH C-terminal fragment
- Receptor targets
- Intracellular inflammatory signalling (mechanism debated)
- Length
- 3 amino acids
- Molecular mass
- ≈ 342 Da
- Origin
- Fragment of human α-MSH, produced synthetically
- Research area
- Immune & inflammation research
- Also known as
- Lys-Pro-Val, α-MSH (11-13)
What KPV is
The C-terminal tripeptide of α-MSH keeps anti-inflammatory activity in cell models. Some studies suggest it acts inside cells after uptake through the peptide transporter PepT1, rather than through melanocortin receptors.
Because it is so short, KPV is simple to synthesise and characterise, but peptidases also break it down quickly, which complicates interpretation of cell and animal experiments.
What the research literature studies
- NF-κB and cytokine readouts in cultured cells
- Peptide-transporter (PepT1) uptake in intestinal cell models
- Inflammation models in rodents, notably colitis
Evidence rating: 1/5
Limited, preclinical or single-group. Cell and rodent studies. No completed human trials that we know of. See our methodology for how levels are assigned.
- A small literature from a limited number of groups.
- Very short peptides are degraded quickly, so stability data matter.
Regulatory status
KPV is not an approved medicine with the MHRA, EMA or FDA. Research-grade material must not be used in people or animals.
Reviewed November 2026.
KPV at Nordapep: sizes and price per mg
Every size, its price and the cost per milligram, so you can choose the best-value vial for your protocol.
Not currently listed at Nordapep.
Compare KPV
KPV FAQ
Is KPV the same as α-MSH?
No. α-MSH has 13 amino acids and KPV is its last three. KPV lacks the central sequence that normally binds melanocortin receptors strongly.
Where can I buy KPV for research?
Nordapep does not currently list KPV. You can ask Nordapep about availability, or compare related compounds that are in stock.
Is KPV approved?
KPV is not an approved medicine with the MHRA, EMA or FDA. Research-grade material must not be used in people or animals.
Key terms for KPV
Cite this page
peptide.wiki. (2026). KPV: research peptide profile. peptide.wiki. https://www.peptide.wiki/peptides/kpv